Şişli Anadolu Lisesi binası İstanbul İli Şişli İlçesi Feriköy semtinde bulunan Paşa Mahallesi'nde 1972 yılında inşa edilerek Şişli İlçesi Mahmut Şevket Paşa İlkokulu bünyesinde bulunan Feriköy Ortaokuluna tahsis edilerek öğretime başlamıştır. Cumhuriyetimizin kuruluşunun 50. yılında mevcut bina 50. Yıl Feriköy Lisesi adını almış, öğretime 1993 yılına kadar devam ettikten sonra aynı yıl Feriköy 50. Yıl Lisesi kapatılarak Ahmet Yesevi İlköğretim Okulu isimli yeni bir okul açılmıştır. Şişli Anadolu Lisesi 1995-1996 Eğitim-Öğretim yılında önceleri Ahmet Yesevi binasında Şair Fuzuli Anadolu Lisesi adı altında 4 hazırlık sınıfı ve 144 öğrenci ile ilk eğitime başlamıştır. Şişli Milli Eğitim Müdürlüğü'nün 26.07.1996 tarih ve 420 / 2208 sayılı emriyle okulumuzun adı Şair Fuzuli Anadolu Lisesi olmuştur. 1996-1997 öğretim yılı sonunda devam etmekte olan Ahmet Yesevi İlköğretim Okulu kapatılarak bina tamamen Şair Fuzuli Anadolu Lisesi'ne devredilmiştir. Şişli İlçe Milli Eğitim Müdürlüğü'nün 22.04.1998 tarih ve 420/19384 sayılı emirleri ve velilerin isteği üzerine okulumuzun adı "Şişli Anadolu Lisesi" olarak değiştirilmiştir. Okulumuz 1995 yılından bugüne; Şişli ilçesine layık vizyon ve misyon sahibi, nitelikli bireyler yetiştirmek ve topluma kazandırılmak amacıyla Eğitim ve Öğretime devam etmekte olup, karma eğitim yapılmaktadır.

Şişli Anatolian High School is a prestigious high school located in İstanbul, Turkey. The name "Şişli" is also the name of the district, one of Istanbul’s central districts. It has been established in 1995. There are more than 500 students aged 14 – 18 and 34 teachers. Students are accepted to our school according to their academic success during their secondary school and the result of the entrance exam that they attend at the end of the secondary school known as LGS. English and German are two foreign languages which are taught in our school. With our progressive success in university placement tests, the school becomes more popular and highly demanded among the ones in the city. Şişli Anatolian High School prides itself on the quality of its educational programs, its staffs’ professionalism, and the enthusiasm of the students. Our students are eager to take part in varied activities like competitions, sports, clubs, workshops, musical ensembles, and theatres. Şişli Anatolian High School is located Feriköy in Şişli. Because the building is very old, the building is decided to be demolished and renewed. Because of this reason we are in another high school located in Mecidiyeköy in Şişli. The new building will be completed by the end of the 2023-2024 academic year. The new campus will be equipped with a sports hall, library with more than 1500 books, cafeteria, sickroom, ICT room, chemistry, biology, physics laboratories, and a conference hall. Since 2012 school participated in Fatih Project and all the classes have smartboards that are actively in use. Our school is also experienced in international projects. We have recently participated in an Erasmus+ strategic partnership project named "Exploring sustainability in the food sector", with a group of schools from Germany, Finland, and Italy and finished the Project. What’s more, we carry out national and international projects interdisciplinary. Besides these, we are running two eTwinning projects and the two projects won National Quality Label. Besides students runs social responsibility projects with NGOs. Within the school, we take note of the social well-being of our students and related elements of our students. So, we have social responsibility projects in which they have different roles to identify themselves, carry out The Duke of Edinburgh's International Award which makes them improve themselves in so many ways, and have art projects reflecting our students’ feelings and thoughts. To have a brighter future, we believe that the youth need to be empowered. So Şişli Anatolian High School always tries to have a democratic environment giving opportunities to enlighten their minds and broaden their scopes. To do so, we have a counseling service that carries out academic and physiological projects. Our students have participated in Model of United Nations (MUN) Conferences and got some awards. Last but not the least, we have more than 5 school magazines prepared by the students under the supervision of their teachers. In these magazines, they can reflect their thoughts freely and have the opportunity of following scientific, cultural, and social developments like a journalist.